Table 1. Haplogroup distribution in glaucoma patients and controls.
|
Mitochondrial haplogroup |
Controls
(n=552) |
Glaucoma patients (n=107) |
Odds ratio |
95% C.I. |
p-Value |
| H |
47 (8.5%) |
7 (6.5%) |
0.75 |
0.30–1.79 |
0.62 |
| I |
5 (0.9%) |
1 (0.9%) |
1.03 |
0.17–6.20 |
1 |
| J |
116 (21%) |
22 (20.6%) |
0.97 |
0.56–1.67 |
0.98 |
| K |
22 (4%) |
4 (3.7%) |
0.94 |
0.27–2.95 |
1 |
| L0 |
6 (1.1%) |
1 (0.9%) |
0.86 |
0.14–5.44 |
1 |
| L1 |
3 (0.5%) |
2 (1.9%) |
3.49 |
0.40–25.9 |
0.19 |
| L2 |
20 (3.6%) |
6 (5.6%) |
1.58 |
0.555–4.29 |
0.41 |
| L3 |
22 (4%) |
5 (4.7%) |
1.18 |
0.38–3.39 |
0.79 |
| L4 |
1 (0.2%) |
2 (1.9%) |
10.5 |
0.74–294.9 |
0.07 |
| L5 |
4 (0.7%) |
2 (1.9%) |
2.61 |
0.33–16.70 |
0.25 |
| M |
17 (3.1%) |
0 |
0.15 |
0.009–2.46 |
0.09 |
| M1 |
19 (3.5%) |
6 (5.6%) |
1.67 |
0.58–4.56 |
0.27 |
| N |
41 (7.4%) |
1 (0.9%) |
0.12 |
0.01–0.81 |
0.02 |
| preHV1 |
99 (17.9%) |
31 (29%) |
1.87 |
1.13–3.06 |
0.0127 |
| R |
17 (3.1%) |
0 |
0.15 |
0.009–2.46 |
0.09 |
| T |
34 (6.2%) |
4 (3.7%) |
0.59 |
0.17–1.80 |
0.45 |
| U |
58 (10.5%) |
10 (9.4%) |
0.88 |
0.41–1.85 |
0.85 |
| W |
6 (1.1%) |
0 |
0.425 |
0.024–7.67 |
0.59 |
| X | 15 (2.7%) | 3 (2.8%) | 1.03 | 0.23–3.88 | 1.0 |
Since we have 19 mitochondrial haplogroups, the Bonferroni correction should be 0.05/19=0.0026. Thus, a p-value<0.0026 was considered significant.