Table 2. Haplogroup distribution in patients with various types of glaucoma and controls.
|
Mitochondrial haplogroup |
Controls (n=552) |
Glaucoma patients (n=107) |
|||||
|
PACG (n=29) |
p-Value |
PEG (n=29) |
p-Value |
POAG (n=49) |
p-Value |
||
| H |
47 |
1 |
0.49 |
1 |
0.49 |
5 |
0.6 |
| I |
5 |
0 |
1 |
0 |
1 |
1 |
0.4 |
| J |
116 |
3 |
0.24 |
10 |
0.1 |
9 |
0.85 |
| K |
22 |
2 |
0.34 |
2 |
0.34 |
0 |
0.24 |
| L0 |
6 |
0 |
1 |
0 |
1 |
1 |
0.45 |
| L1 |
3 |
0 |
1 |
0 |
1 |
2 |
0.06 |
| L2 |
20 |
5 |
0.005 |
0 |
0.62 |
1 |
1 |
| L3 |
22 |
0 |
0.62 |
0 |
0.62 |
5 |
0.06 |
| L4 |
1 |
0 |
1 |
0 |
1 |
2 |
0.02 |
| L5 |
4 |
0 |
1 |
0 |
1 |
2 |
0.08 |
| M |
17 |
0 |
1 |
0 |
1 |
0 |
0.35 |
| M1 |
19 |
1 |
1 |
1 |
1 |
4 |
0.11 |
| N |
41 |
0 |
0.25 |
0 |
0.25 |
1 |
0.24 |
| preHV1 |
99 |
15 |
0.00002 |
8 |
0.22 |
8 |
1 |
| R |
17 |
0 |
1 |
0 |
1 |
0 |
0.38 |
| T |
34 |
1 |
1 |
2 |
0.69 |
1 |
0.35 |
| U |
58 |
0 |
0.1 |
4 |
0.54 |
6 |
0.63 |
| W |
6 |
0 |
1 |
0 |
1 |
0 |
1 |
| X | 15 | 1 | 0.56 | 1 | 0.56 | 1 | 1 |
Since we have 19 mitochondrial haplogroups, the Bonferroni correction should be 0.05/19=0.0026. Therefore, a p-value<0.0026 was considered significant. In the case of comparing the haplogroup distribution among each of the three different glaucoma groups with the controls, the threshold was further reduced to 0.00087. The only significant p-value is in bold.