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. 2008 Mar 20;118(4):1553–1562. doi: 10.1172/JCI33998

Figure 9. Killing of smooth wild-type NTS and a rough NTS mutant by Malawian adult and child serum, heat-inactivated serum, and C9-deficient serum.

Figure 9

In vitro killing by serum of smooth wild-type S. Typhimurium D23580 and a deep rough mutant of D23580 with disrupted galE gene at 45, 90, and 180 minutes (initial concentration, 106 salmonellae/ml). (A) Killing of mutant rough D23580 by adult serum (circles) and child serum lacking Salmonella-specific antibody (diamonds) and of wild-type smooth D23580 by adult serum (squares) and child serum lacking Salmonella-specific antibody (triangles). (B) Killing of rough D23580 by child serum lacking Salmonella-specific antibody (squares) was maintained in the presence of 10 mM EGTA and MgCl2 (triangles). Killing of rough D23580 did not occur in heat-inactivated serum (circles) or C9-deficient serum (diamonds), but addition of exogenous C9 to C9-deficient serum induced killing (x). Data are mean ± 1 SD of 3 experiments.