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. Author manuscript; available in PMC: 2008 Mar 18.
Published in final edited form as: Psychopharmacology (Berl). 2002 Aug 30;164(2):168–176. doi: 10.1007/s00213-002-1192-1

Fig. 3.

Fig. 3

The ability of OFQ/N to block cocaine-induced motor stimulation was blocked by pretreatment with J-113397, an ORL-1 receptor antagonist. Rats were treated with vehicle (V, 20% DMSO) or J-113397 (J; 30 nmol, ICV) 15 min prior to aCSF or OFQ/N (15 nmol, ICV) followed by cocaine (20 mg/kg, IP). Rats were treated similarly for 3 days, except the dose of OFQ/N was doubled on day 2 and again on day 3. Data are means±SEM of five to eight rats/group