Figure 4. The level of EPO expression and its physiological effect in rhesus monkeys is dose-dependent.
The animals were injected either with the CMV-RhEPO or mMCK-RhEPO construct at 6 mg/kg or 3 mg/kg dose. Panel A shows serum EPO concentrations at various time points while panel B illustrates the resulting physiological response leading to elevated hematocrit values. Group averages and SEM values are shown.