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. Author manuscript; available in PMC: 2008 Mar 18.
Published in final edited form as: Hum Gene Ther. 2007 Mar;18(3):269–285. doi: 10.1089/hum.2006.186

Figure 5. The kinetics of serum EPO changes and of the ensuing physiological response are promoter-dependent.

Figure 5

On day 0 animals were injected either with the CMV-RhEPO, mMCK-RhEPO or hMCK-RhEPO construct at 6 mg/kg dose. Serum EPO levels (A) and hematocrit values (B) were determined at various time points. The average and the SEM of results from 3–6 injections per condition are shown. Panel C shows both the serum EPO concentrations and the hematocrit values for two individual animals injected either with a single 6 mg/kg dose of mMCK-RhEPO (animal #139-03) or with two identical, repeated 6 mg/kg doses of CMV-RhEPO on day 0 and day 140, followed by a third delivery of 6 mg/kg of mMCK-RhEPO on day 294 (animal #139-02). Arrows mark the time of injections. The asterisk marks the time when therapeutic phlebotomy was performed on animal #139-02 to lower the hematocrit below 60%.