. Author manuscript; available in PMC: 2009 Feb 15.

Published in final edited form as: Bioorg Med Chem. 2007 Nov 5;16(4):1903–1913. doi: 10.1016/j.bmc.2007.11.001

Table I.

Reactivity pattern matrix for the panel of eight selected Fabs. The epitope mapping results revealed four different epitopes exist on PA. Fab A8 recognizes a distinct epitope. Fab F1 and G12, F11 and G3, and G11, H2 and 83H2 recognize a similar epitope, respectively. The later three clusters also have epitope overlapping with each other in some extent.

		Second Probe
		A8	F1	F11	G3	G11	G12	H2	83H2
First Probe	A8	^✘	^✓	^✓	^✓	^✓	^✓	^✓	^✓
	F1	^✓	^✘	UC	UC	UC	^✘	^✓	^✓
	F11	^✓	UC	^✘	^✘	UC	UC	^✓	^✓
	G3	^✓	UC	^✘	^✘	UC	UC	^✓	^✓
	G11	^✓	UC	UC	UC	^✘	UC	^✘	^✘
	G12	^✓	^✘	UC	UC	UC	^✘	^✓	^✓
	H2	^✓	^✓	^✓	^✓	^✘	^✓	^✘	UC
	83H2	^✓	^✓	^✓	^✓	^✘	^✓	UC	^✘

^✘

Recognition of the same or a very similar epitope;

^✓

recognition of a different epitope; UC: uncertain, may recognize an overlapping or slightly shifted epitope.