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Sensitivity of HIV-1 R5 envelopes to the CD4bs mab, b12. Pseudovirions carrying envelopes encoded by envelope genes amplified from patient samples were tested for sensitivity to inhibition by b12. All but one of the macrophage-tropic envelopes (light symbols) were sensitive to b12, while many non-macrophage-tropic envelopes (dark symbols) were resistant.
