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Sensitivity of HIV-1 R5 envelopes to 2G12. Pseudovirions carrying envelopes encoded by envelope genes amplified from patient samples were tested for sensitivity to inhibition by 2G12. Macrophage-tropic envelopes (light symbols) and non-macrophage-tropic envelopes (dark symbols) were examined. Statistical analysis showed a significant correlation between macrophage-tropism and sensitivity to 2G12.
