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. 2008 Jan 18;5:5. doi: 10.1186/1742-4690-5-5

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Copyright © 2008 Peters et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Intrapatient variation of HIV-1 R5 envelope macrophage-tropism and sensitivity to reagents that inhibit gp120 interactions with CD4 and CCR5. Brain-derived envelopes (light symbols) from patient NA420 (left panels) and NA20 (right panels) were more sensitive to PRO 542, b12, TAK779 and SCH350581, but more resistant to anti-CD4, Q4120, compared to LN-derived envelopes (dark symbols). NA420 envelopes tested were B13 (light squares), B33 (light triangles), B42 (light diamonds), LN85 (dark circles) and LN40 (dark triangles). NA20 envelopes tested were B59 (light squares), B76 (light triangles), B501 (light diamonds), LN3 (crosses), LN8 (dark circles), LN10 (dark diamonds), LN14 (dark triangles) and LN16 (dark squares).