Table 2.
Changes in LIC and serum ferritin by initial dose and disease group (for patients with end-of-study LIC assessment, n = 147)
| Initial dose, mg/kg/d | Change in iron burden (based on available values) | MDS (n = 28) | DBA (n = 26) | Other anaemias (n = 17) | β-Thalassaemia (n = 76) |
|---|---|---|---|---|---|
| 5 | Patients | 3 | 1 | 0 | 1 |
| Change in serum ferritin, μg/L | 2620 ± 2473 | 2473 | – | 2071 | |
| Change in LIC, mg Fe/g dw | 7.4 ± 4.9 | 7.6 | – | 11.4 | |
| 10 | Patients | 6 | 3 | 0 | 8 |
| Change in serum ferritin, μg/L | 196 ± 1097 | 1084 ± 392 | – | 1116 ± 642 | |
| Change in LIC, mg Fe/g dw | −3.4 ± 5.6 | 5.7 ± 6.2 | – | 6.5 ± 3.2 | |
| 20 | Patients | 7 | 7 | 8 | 17 |
| Change in serum ferritin, μg/L | −410 ± 1632 | −364 ± 1002 | −894 ± 957 | 385 ± 876 | |
| Change in LIC, mg Fe/g dw | −10.7 ± 5.2 | −4.6 ± 6.6 | −3.2 ± 7.0 | −1.1 ± 4.2 | |
| 30 | Patients | 12 | 15 | 9 | 50 |
| Change in serum ferritin, μg/L | −1581 ± 1653 | −143 ± 1328 | −443 ± 1906 | −1019 ± 1651 | |
| Change in LIC, mg Fe/g dw | −9.4 ± 5.9 | −3.2 ± 8.4 | −4.4 ± 7.6 | −8.0 ± 8.5 | |
| All | Chelation efficiency, % | 33.9 ± 20.0 | 26.7 ± 16.1 | 26.6 ± 15.0 | 26.7 ± 12.3 |