Table 1.

Blood gas values and arterial pH (pH_a) recorded during air-breathing and at the 5th minute of hypoxia (8% O₂) before and after administration of L-NAME or glibenclamide at 10 or 20 mg kg⁻¹ I.V.

	Pa,O2(mmHg)	Pa,CO2(mmHg)	pHa
Before L-NAME
Air	82.4 ± 2	45.1 ± 1	7.40 ± 0.01
8% O2	39.1 ± 2	35.7 ± 1	7.46 ± 0.01
After L-NAME (10 mg kg−1)
Air	84.7 ± 2	44.6 ± 1	7.38 ± 0.01**
8% O2	40.2 ± 2	35.6 ± 1	7.43 ± 0.01***
Before glibenclamide
Air	84.9 ± 1	48.1 ± 1	7.34 ± 0.01
8% O2	33.5 ± 2	35.0 ± 2	7.41 ± 0.01
After glibenclamide (10 mg kg−1)
Air	90.1 ± 3	50.8 ± 2	7.32 ± 0.02
8%O2	35.1 ± 1	37.7 ± 2	7.38 ± 0.02*
Before glibenclamide
Air	87.6 ± 5	49.7 ± 2	7.39 ± 0.02
8% O2	34.6 ± 1	34.6 ± 1	7.49 ± 0.02
After glibenclamide (20 mg kg−1)
Air	90.6 ± 3	51.8 ± 3	7.38 ± 0.01
8% O2	32.2 ± 1	41.1 ± 3	7.45 ± 0.02*

P_a,O2, arterial O₂ pressure; P_a,CO2, arterial CO₂ pressure. Values are means ± S.E.M.

^***P < 0.001

^**P < 0.01

^*P < 0.05

significant difference between values recorded before and after drug.