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. 1999 Feb 1;514(Pt 3):783–793. doi: 10.1111/j.1469-7793.1999.783ad.x

Figure 4. Cystine has no effect on GLAST and EAAT4/EAAC1 transporter currents.

Figure 4

A, membrane current at -63 mV of an isolated salamander retinal glial cell (which expresses mainly GLAST transporters) during the application of 10 μM glutamate (as indicated by bars) in the absence and presence of 1 mM cystine. B, membrane current at -33 mV of a Purkinje cell (in solution containing 25 μM 2,3-dihydroxy-6-nitro-7-sulphamoyl-benzene(f)quinoxaline (NBQX), 50 μM AP5 and 20 μM bicuculline) during iontophoresis of D-aspartate (D-asp, bars) which activates EAAT4 and EAAC1 transporters. The transporter currents (shown before, during and after washout (left to right) of solution containing cystine) were not affected by the presence of 1 mM cystine.