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. 1999 Feb 15;515(Pt 1):19–30. doi: 10.1111/j.1469-7793.1999.019ad.x

Figure 8. Steady-state dependence of mutant KATP channel activities on [AMP], [ADP] and [adenosine tetraphosphate].

Figure 8

Dependence of membrane current (relative to current in zero adenosine nucleotide) on [adenosine nucleotides] for wild-type and mutant channels (as indicated). Data points represent the mean ±s.e.m. (n = 3-10 patches). The data were fitted as described in Fig. 3. Ki for AMP = 1.8 mM (wild-type), 31.9 mM (Kir6.2ΔN2−30 + SUR1), and 13.6 mM (Kir6.2K185Q + SUR1). Not determined for Kir6.2ΔN2−30/K185Q + SUR1. Ki for ADP = 144 μM (wild-type), 1.1 mM (Kir6.2ΔN2−30 + SUR1), 2.5 mM (Kir6.2K185Q + SUR1), and 7.1 mM (Kir6.2ΔN2−30/K185Q + SUR1). Ki for adenosine tetraphosphate = 6 μM (wild-type), 124 μM (Kir6.2ΔN2−30 + SUR1), 680 μM (Kir6.2K185Q + SUR1), and 8.8 mM (Kir6.2ΔN2−30/K185Q + SUR1).