Figure 5. Voltage dependence of intramembrane charge movements.

A, non-linear charge moved during repolarization (Q_off) plotted versus the charge moved during depolarization (Q_on). The continuous line indicates equality of Q_on and Q_off. Both in controls (open symbols) and after application of 5 μM 4-CmC (filled symbols) on-off charge equality was maintained up to a depolarization of 0 mV (circles). A deviation from the line occurred at the potential of +10 mV (squares). B, charge density as a function of membrane potential. Integrals of ‘on’ and ‘off’ non-linear currents were averaged. ○, controls; •, after application of 4-CmC. Averaged data from 8 experiments.