Figure 3. Development of slow inactivation in Na⁺ channel chimaeras is intermediate relative to that in hH1 and in μ1.

Data were collected as described in Fig. 2. A, development of slow inactivation in μ1₍₁₎hH1_(2,3,4) is more similar to that in hH1 than to that in μ1. Normalized representative traces for hH1 (continuous lines) and μ1₍₁₎hH1_(2,3,4) (dashed lines) before (larger traces) and after (smaller traces) depolarization to 0 mV for 120 s are shown. B, mean ±s.e.m. values for hH1 (▪, continuous line; n = 11) and μ1₍₁₎hH1_(2,3,4) (□, dashed line; n = 8) were fitted with a double exponential function. *P < 0.05vs. hH1. C, normalized traces from μ1 (continuous lines), μ1_(1,2)hH1_(3,4) (dotted lines), and μ1_(1,2,3)hH1₍₄₎ (dashed lines) before and after depolarization to 0 mV for 120 s to induce slow inactivation. D, mean ±s.e.m. values for μ1 (•, continuous line; n = 10), μ1_(1,2)hH1_(3,4) (▵, dotted line; n = 8) and μ1_(1,2,3)hH1₍₄₎ (○, dashed line; n = 10) were fitted with a double exponential function. *P < 0.05vs.μ1.