Table 1.
Average number of ipsilateral or contralateral neurones in DRG expressing α2A-AR (L4, L5) or α2C-AR (L4 only) in unoperated animals and animals with partial or complete sciatic transection or inflammation
| Normal | Partial | Complete | Inflammation | |
|---|---|---|---|---|
| α2A-like-IR | ||||
| Ipsilateral L4 | 19.2 ± 5.8 | 135.2 ± 46.5 | 194.3 ± 57.3 | 12.8 ± 3.4 |
| Contralateral L4 | 20.3 ± 5.7 | 21.4 ± 8.7 | 27.7 ± 9.4 | 16.1 ± 7.4 |
| α2A-like-IR | ||||
| Ipsilateral L5 | 16.3 ± 1.0 | 238.3 ± 65.1 | 125.5 ± 52.3 | — |
| Contralateral L5 | 15.2 ± 1.1 | 34.4 ± 14.7 | 21.4 ± 9.2 | — |
| α2C-like-IR | ||||
| Ipsilateral L4 | 17.4 ± 5.4 | 13.6 ± 5.7 | 16.2 ± 7.6 | 17.2 ± 5.1 |
| Contralateral L4 | 17.1 ± 5.2 | 11.8 ± 3.2 | 18.4 ± 5.4 | 19.5 ± 5.4 |
Normal, unoperated animals (n = 8); Partial, 7–14 days after partial sciatic transection (n = 7); Complete, complete sciatic transaction (n = 11); Inflammation, 1–14 days after injection of Freund's adjuvant (n = 4). Data are means ± S.D. The range of the number of positive cells in 10 sections in different animals was as follows. α2A-AR-IR normal: ipsilateral (IL), L4, 12.8–27.1; contralateral (CL), L4, 11.4–24.7; IL, L5, 14.5–17.5; CL, L5, 14.0–16.5. Partial sciatic transection: IL, L5, 82.1–184.2; CL, L5, 12.2–32.3; IL, L5, 118.5–315.0; CL, L5, 20.1–61.2. Complete sciatic transection: IL, L5, 71.5–257.0; CL, L5, 8.8–35.4; IL, L5, 31.2–195.6; CL, L5, 10.2–35.6. Inflammation: IL, L4, 8.7–17.4; CL, L4, 8.1–26.8. For α2C-AR-IR, as follows. Normal: IL, L4, 11.8–23.2; CL, L4, 12.5–24.1. Partial sciatic transection: IL, L4, 4.2–20.5; CL, L4, 3.5–25.3. Complete sciatic transection: IL, L4, 8.5–28.2; CL, L4, 9.2–29.1. Inflammation: IL, L4, 10.3–22.4; CL, L4, 10.7–25.2.