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. 1999 Mar 1;515(Pt 2):453–462. doi: 10.1111/j.1469-7793.1999.453ac.x

Figure 4. NO impairs the induction of LTP in a time-dependent manner.

Figure 4

A, the time course of the depressive action of photolytically released NO on NMDA receptor-mediated transmission is plotted against time. The plot is pooled data from six experiments and the s.e.m. is plotted for every fifth mean (responses evoked at 0.1 Hz). A single 1 ms pulse of near-UV light was applied at time zero (inverted arrow), releasing 4.5 μM NO. The inset shows the early effects of NO on NMDA receptor-mediated transmission on an expanded time base. The arrows indicate time zero, and elapsed times at 30 s and 60 s after photolysis. B, the mean slope of normal synaptic responses is plotted against time and the s.e.m. is plotted for every fifth mean. Each slice was exposed to 500 μM caged NO throughout. A tetanus was applied at the time indicated (▴). Slices were exposed to photolytically released NO (4.5 μM) either in conjunction with the first shock of the conditioning train (•, n = 5), or 30 s (○, n = 5), 60 s (▪, n = 6), or 10 min (□, n = 6) before tetanic stimulation. Experiments performed at 24 °C.