Figure 1. cpt-cAMP inhibits an outward potassium current in sensory neurones.

Outward potassium currents are shown from a representative sensory neurone in the absence (left panels) and presence (right panels) of 100 μM cpt-cAMP. In the top panels, I_K was activated by incremental 20 mV steps from a holding potential of -60 mV (see inset). The bottom panels represent the currents obtained from this neurone using the steady-state inactivation protocol (see inset) before (left) and 20 min after (right) application of cpt-cAMP. In the bottom panels, the beginnings of the traces are the last 300 ms of the conditioning prepulses.