Table 1.

Effects of cpt-cAMP, PGE₂ and PKI on the voltage dependence of I_K activation

		V0.5 (mV)	k (mV)	G/Gmax
Control†		4 ± 2	17 ± 1	1.0
cpt-cAMP	2 min	7 ± 2	18 ± 1	0.92 ± 0.02*
	6 min	7 ± 3	18 ± 1	0.85 ± 0.04*
	10 min	6 ± 2	17 ± 1	0.76 ± 0.03*
	20 min	5 ± 2	17 ± 1	0.69 ± 0.02*
Control†		1 ± 2	14 ± 1	1.0
PGE2	2 min	1 ± 2	15 ± 1	0.90 ± 0.02*
	6 min	1 ± 3	15 ± 1	0.81 ± 0.03*
	10 min	2 ± 3	15 ± 1	0.73 ± 0.03*
	20 min	−1 ± 3	16 ± 1	0.64 ± 0.05*
Control + PKI‡		5 ± 2	15 ± 1	1.0
PGE2+ PKI	20 min	5 ± 2	17 ± 1	0.97 ± 0.05

Values are means ± S.E.M.

^*Significant difference from respective controls

^†n = 10

^‡n = 7.