Table 1.
Human α3 AChR single channel properties
| Conductance (pS) | Mean open time (ms) | Mean burst time (ms) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| AChR | γ1 | γ2 | γ3 | τ1 | τ2 | τ3 | τ1 | τ2 | τ3 |
| α3β2 | 21 ± 1 | 26 ± 1 | — | 0.71 ± 0.14 | 3.5 ± 0.4 | — | 0.82 ± 0.1 | 25.3 ± 0.7 | — |
| (22 ± 6%, | (78 ± 6%, | — | (65 ± 4%, | (35 ± 4%, | — | (57 ± 4%, | (43 ± 4%, | — | |
| 6/7) | 7/7) | — | 6/6) | 6/6) | — | 6/6) | 6/6) | — | |
| α3α5β2 | 22 ± 1 | 26 ± 1 | — | 0.50 ± 0.10 | 2.1 ± 0.3 | 5.5 ± 0.3 | 0.90 ± 0.28 | 5.0 ± 1.0 | — |
| (50 ± 19%, | (60 ± 18%, | — | (76 ± 1%, | (42 ± 15%, | (34 ± 18%, | (56 ± 14%, | (44 ± 14%, | — | |
| 4/5) | 5/5) | — | 4/5) | 3/5) | 3/5) | 5/5) | 5/5) | — | |
| α3β4 | 24 ± 1 | 31 ± 1 | — | 1.4 ± 0.2 | 6.5 ± 0.8 | — | 1.7 ± 0.2 | 16 ± 1.0 | — |
| (50%, | (90 ± 10%, | — | (50 ± 7%, | (50 ± 7%, | — | (54 ± 4%, | (56 ± 4%, | — | |
| 1/5) | 5/5) | — | 5/5) | 5/5) | — | 5/5) | 5/5) | — | |
| α3α5β4 | 24 ± 1 | 31 ± 1 | 36 ± 1 | 1.6 ± 0.2 | 6.4 ± 0.7 | 22 ± 3 | — | 6.2 ± 0.4 | 43 ± 4 |
| (39 ± 6%, | (81 ± 6%, | (51 ± 24%, | (52 ± 8%, | (57 ± 9%, | (26 ± 5%, | — | (64 ± 7%, | (39 ± 7%, | |
| 3/10) | 9/10) | 3/10) | 7/10) | 7/10) | 8/10) | — | 9/10) | 8/10) | |
| IMR-32 | — | 32 ± 1 | — | 1.5 ± 0.3 | 9.6 ± 1.2 | — | 1.6 ± 0.4 | 25 ± 3.0 | — |
| — | (100%, | — | (48 ± 7%, | (52 ± 7%, | — | (54 ± 7%, | (46 ± 7%, | — | |
| — | 5/5) | — | 4/4) | 4/4) | — | 3/4) | 4/4) | — | |
Conductance values were calculated as described in Methods. All values are means ± S.E.M.; — indicates component not present. Values in parentheses reflect percentage of area under distribution representing component when present, and fraction of patches having component.