Figure 4. Effects of the different peptides on single gap junctional channel conductance.

A, junctional current traces (I_j) recorded in response to V_j of 50 mV just before complete uncoupling induced by halothane treatment. Opening and subsequent closure of individual channels of different sizes can be discerned in A7r5 cell pairs. B-E, frequency histograms of conductance changes were determined from the amplitudes of single channel events in I_j recorded in response to V_j of 50 mV. Bin width, 8 pS. A7r5 cell pairs under control conditions (B), after incubation with P314-322 (C), after incubation with P180-195 (D), and after incubation with P177-192 (E).