Figure 1.

Effects of TGB on CSSP and PPI₁₆₀ at different dosages

A, example of one subject: four representative trials demonstrating CSSP are shown at baseline (top) and at different doses of TGB, ranging from 5 to 15 mg, as indicated. CSSP duration increased with increasing doses of TGB. Baselines for 10 and 15 mg experiments are indicated as vertical lines. B, averages of 20 trials testing PPI₁₆₀ are shown. Results are from the same subject. Suppression of the amplitude of the second response was augmented by TGB. C, dose dependency of the effects of TGB on CR160 (▪), CR3 (▵), CR10 (⋄) and CSSP (▴) in three subjects. Effects are expressed as the percentage difference of CR160_TGB, CR3_TGB or CR10_TGB from the baseline condition (no TGB) (left ordinate), or as the duration difference (ms) of CSSP_TGB from baseline (right ordinate).