Figure 4. Effects of AsODNs targeted against Kv4.3 and Kv4.2 are specific.

Representative normalized K⁺ currents recorded from HEK-293 cells expressing Kv4.3 (A) or Kv4.2 (D) are displayed; currents were recorded as described in the legend to Fig. 1. The Kv4.3-induced K⁺ currents (A) were decreased following incubation with the Kv4.3 AsODN (C), but not after exposure to the Kv4.2 AsODN (B). Similarly, the currents produced on expression of Kv4.2 (D) were significantly attenuated by the Kv4.2 AsODN (F), whereas the Kv1.5 AsODN did not have any measurable effects (E).