Figure 7. Effect of AsODNs on the peak atrial outward K⁺ current density-voltage relations.

Outward currents, evoked during 100 ms depolarizing voltage steps to potentials from -50 to +50 mV from a holding potential of -60 mV, were recorded in P28 rat atrial myocytes under control conditions or following exposure to Kv α subunit AsODNs (see Fig. 5). Peak outward currents were measured in individual cells and normalized to the whole-cell membrane capacitance, C_m (determined in the same cell). Mean ±s.e.m. peak outward K⁺ currents densities are plotted here as a function of test potential. Peak outward K⁺ current densities were reduced significantly (P < 0.01) in cells exposed to the Kv1.2, Kv1.5 and Kv4.2 AsODNS, whereas no significant effects on the currents were evident in cells treated with Kv2.1, Kv4.3 or KvLQT1 AsODNs.