Figure 8. Superfusion of sodium butyrate increased dose dependently the excitability of mucosally projecting myenteric AH neurones.

Sodium butyrate effects were expressed as percentage increase in the number of current pulses that evoked action potentials during a 1 min period in the presence of butyrate compared with 1 min pre-butyrate values. All concentrations of butyrate induced a significant increase in the number of pulses inducing action potentials. This was significantly more pronounced for 10 mM butyrate when compared with 1 or 0.1 mM. For the control period depolarizing pulses were set to suprathreshold values, had a 300 ms duration and were delivered at 0.3 Hz. The number of cells tested is indicated. * P < 0.05 compared with control.