Figure 3. Concentration-response curves to acetylcholine in mesenteric small arteries from virgin rats fed a control (○; n = 10) or saturated fat diet (•; n = 10).
A, without inhibitors. B, in the presence of 10 μm indomethacin. C, in the presence of 100 μm L-NAME, 10 μm indomethacin and 1 μm ODQ and also with the same inhibitors but in the presence of depolarizing 25 mM KCl to obviate the effects of endothelium-derived hyperpolarizing factor (EDHF) (▵, control diet; ▴, saturated fat diet). Values are given as means ±s.e.m. pEC50: ***P < 0.001.