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Addition of forskolin (Fsk) to the basolateral side of isolated colon epithelium resulted in an immediate increase in transepithelial short-circuit current, ISC, consistent with anion secretion. This representative trace shows that secretion was inhibited by blockade of basolateral Na+-K+-2Cl− cotransport with bumetanide (100 μM) and Cl−-HCO3− exchange with DIDS (100 μM). Replacement of basolateral Cl− with gluconate also prevented this response.
