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. 1999 Aug 15;519(Pt 1):153–168. doi: 10.1111/j.1469-7793.1999.0153o.x

Figure 7. Effect of 8,9-EET on single Na+ channel opening probability.

Figure 7

Representative single channel recordings in cell-attached membrane patches of rat ventricular myocytes with a holding potential of −100 mV and a test potential of −40 mV before (control) and after application of 5 μM 8,9-EET are shown in A. In the presence of EET, the number of null sweeps is significantly increased. The ensemble-averaged currents from 500 sweeps before (control) and after application of 5 μM 8,9-EET are shown in B. C represents the results from seven experiments measuring single Na+ channel opening probability (Po) under control conditions and in the presence of 5 μM 8,9-EET. Po is 0.270 ± 0.027 for the controls, and 8,9-EET markedly reduced Po to 0.048 ± 0.026.