Figure 7. Effect of superfusion of the coeliac plexus with zaprinast on the gastroduodenal inhibitory reflex.

All recordings were obtained from the same preparation. In the presence of Krebs solution, gastric distension (50 ml, 5 min) induced an increase in the amplitude of duodenal contractions over 10 min (A). When the coeliac plexus was superfused with L-arginine (5 × 10⁻⁴ M), gastric distension elicited a marked (P≤ 0.001) inhibitory reflex (latency, 1 min and duration, 9 min) (B). In the presence of L-arginine (5 × 10⁻⁴ M) + zaprinast (5 × 10⁻⁵ M), the duration of the inhibitory reflex was significantly enhanced (14 min) (C).