Table 1.
Genotypes of the progeny from hemizygous matings
| Stage | Total | Genotyped | FII genotype
|
||||
|---|---|---|---|---|---|---|---|
| +/+ | +/− | −/− | %* | ||||
| E8.5 | 37 | 34 | 10 | 16 | 8 | 23.5 | P = 0.82† |
| E9.5 | 76 | 73 | 15 | 39 | 18 (1)‡ | 25.4 | P = 1.0 |
| E10.5 | 104 | 103 | 29 | 58 (3) | 7 (6) | 6.8 | P < 0.001 |
| E11.5 | 36 | 32 | 6 (2) | 19 | 3 (2) | 9.4 | P < 0.05 |
| E12.5 | 99 | 86 | 26 (1) | 46 (2) | 8 (3) | 9.3 | P < 0.001 |
| E15.5 | 53 | 48 | 19 | 24 | 5 | 10.4 | P < 0.02 |
| E18.5 | 96 | 95 | 34 | 51 | 10 | 10.5 | P < 0.001 |
| Term | 135 | 134 | 47 | 77 | 10 | 7.4 | P < 0.001 |
*
Viable FII−/− mice calculated as the percentage of all genotyped mice in the same age group.
†
Calculated using χ2 test comparing the expected and observed frequency of viable FII−/− mice.
‡
Number of grossly nonviable mice are listed in parentheses.