Figure 3. Effect of caveolin-1 isoforms on I_Cl,swell in caveolin-1-deficient cell lines.

Caco-2, MCF-7 and T47D cells, either control (con) or transfected with caveolin-1, −1α or −1β as indicated, were subjected to a 25 % HTS and I_Cl,swell was measured. Difference currents (maximal HTS-triggered current minus basal current in isotonic medium) are plotted for the different conditions either at +50 mV (Caco-2) or at +80 mV (MCF-7 and T47D). The boxes correspond to interquartile ranges (25-75 percentile; middle line is median) with error bars representing the 5th (lower) and 95th percentile (upper). Small open square denotes the mean. Asterisks above and below boxes represent the 0th and 100th percentile. The differences between transfected and control conditions were statistically significant.