Table 1.
Effect of 3 h renal perfusion pressure reduction on left renal function, mean arterial pressure and plasma renin activity under chloralose-urethane (CU) anaesthesia in losartan-treated and non-treated rats
| Groups | RPP(mmHg) | RBF (ml min−1 gKw−1) | GFR (ml min−1 gKw−1) | UV (μl min−1 gKw−1) | UNaV (μmol min−1 gKw−1) | FENa (%) | MAP (mmHg) | PRA (ng AngI ml−1 h−1) |
|---|---|---|---|---|---|---|---|---|
| Sham | ||||||||
| Basal values | 103 ± 3 | 10.8 ± 0.5 | 1.16 ± 0.04 | 21.3 ± 2.8 | 4.27 ± 0.60 | 2.44 ± 0.33 | 105 ± 3 | — |
| Expt values | 100 ± 3* | 10.8 ± 0.6 | 1.17 ± 0.06 | 16.8 ± 2.7* | 4.04 ± 0.56 | 2.33 ± 0.34 | 103 ± 3* | 33.7 ± 7.3 |
| 60 mmHg | ||||||||
| Basal values | 106 ± 2 | 10.1 ± 0.4 | 1.32 ± 0.09 | 30.5 ± 5.9 | 6.47 ± 0.91 | 3.21 ± 0.56 | 108 ± 2 | — |
| Expt values | 60 ± 1‡ | 5.5 ± 0.3‡ | 0.73 ± 0.09‡ | 2.3 ± 0.2† | 0.15 ± 0.03† | 0.13 ± 0.02† | 135 ± 3‡ | 251.5 ± 31.6 |
| Los–60 mmHg | ||||||||
| Basal values | 95 ± 4 | 10.8 ± 0.3 | 1.24 ± 0.08 | 30.5 ± 5.1 | 6.85 ± 1.08 | 3.55 ± 0.52 | 97 ± 4 | — |
| Expt values | 60 ± 1‡ | 7.7 ± 0.4‡ | 0.55 ± 0.08‡ | 2.1 ± 0.4† | 0.10 ± 0.04† | 0.14 ± 0.05† | 117 ± 3‡ | 345.4 ± 17.3 |
Values are means ±s.e.m. of basal (Basal values) and experimental (Expt values) periods for renal perfusion pressure (RPP), renal blood flow (RBF), glomerular filtration rate (GFR), urine flow (UV), absolute sodium excretion (UNaV), fractional sodium excretion (FENa) and mean systemic arterial pressure (MAP). Plasma renin activity (PRA) values are means ±s.e.m. at the end of each experiment. gKw, gram kidney weight.
*
P < 0.05
†
P < 0.01
‡
P < 0.001 for comparison between basal and expermental values.