Table 1.
Effects of i.v. administration of saline vehicle, PPADS (20 mg kg−1) or suramin (80 mg kg−1) on baseline values of the variables of mesenteric afferent nerve activity (MNA), intrajejunal pressure (JP), blood pressure (BP) and heart rate (HR)
| MNA(spikes s−1) | JP(cmH2O) | BP(mmHg) | HR(beats min−1) | |
|---|---|---|---|---|
| Saline vehicle (n= 7) | ||||
| Pre | 22 ± 3 (11–33) | 5.3 ± 0.7 (3.0–8.7) | 105 ± 4 (85–115) | 359 ± 16 (315–419) |
| Post | 22 ± 3 (10–32) | 5.5 ± 0.7 (3.1–8.8) | 108 ± 5 (89–119) | 358 ± 15 (305–417) |
| PPADS (n= 5) | ||||
| Pre | 33 ± 8 (21–62) | 4.4 ± 0.7 (3.0–6.7) | 108 ± 13 (84–150) | 350 ± 21 (313–409) |
| Post | 36 ± 8 (28–64) | 4.3 ± 0.2 (3.8–4.6) | 124 ± 15 (88–168)* | 333 ± 17 (304–378)* |
| Suramin (n= 6) | ||||
| Pre | 26 ± 6 (13–43) | 4.7 ± 0.6 (2.9–6.6) | 104 ± 4 (91–111) | 383 ± 11 (358–417) |
| Post | 32 ± 9 (13–56) | 5.6 ± 0.9 (3.1–9.0) | 114 ± 7 (86–133) | 372 ± 14 (333–428) |
Pre, baseline value 1 min before treatment with vehicle or an antagonist; Post, baseline value 5 min after treatment with vehicle or an antagonist. Values are means ±s.e.m. (n, number of animals). The ranges are given in parentheses.
*
P < 0.05, significantly different from values determined before an antagonist treatment.