Table 3.
Effects of I.V. administration of ω-conotoxins MVIIA and SVIB (each at 25 μg kg−1) or alosetron (30 μg kg−1) on baseline values of the variables of mesenteric afferent nerve activity (MNA), intrajejunal pressure (JP), blood pressure (BP) and heart rate (HR)
| MNA(spikes s−1) | JP(cmH2O) | BP(mmHg) | HR(beats min−1) | |
|---|---|---|---|---|
| ω-Conotoxins MVIIA and SVIB (n= 4) | ||||
| Pre | 50 ± 8 (32–65) | 9.2 ± 1.1 (7.4–10.9) | 99 ± 15 (63–124) | 387 ± 28 (352–457) |
| Post | 59 ± 12 (31–72) | 9.3 ± 0.8 (7.6–10.7) | 67 ± 9 (49–85)* | 319 ± 17 (290–359)** |
| Alosetron (n= 5) | ||||
| Pre | 46 ± 9 (24–68) | 7.0 ± 1.0 (4.2–9.8) | 105 ± 15 (54–134) | 430 ± 35 (374–550) |
| Post | 36 ± 6 (23–52)* | 6.9 ± 1.1 (4.0–8.9) | 107 ± 16 (53–127) | 433 ± 35 (365–552) |
Pre, value 1 min before treatment with toxin or antagonist; Post, value 5 min after treatment with toxin or antagonist. Values are means ±s.e.m. (n, number of animals). The ranges are given in parentheses.
**
P < 0.01
*
P < 0.05 significantly different from values determined before treatment with toxin or antagonist.