Figure 1. Effects of hexamethonium on adrenaline and noradrenaline output from perfused rat adrenal glands in response to transmural electrical stimulation and acetylcholine.

Transmural electrical stimulation (ES; A) or acetylcholine infusion (ACh; B) was applied to the adrenal gland in the absence (control, •) or presence of hexamethonium (10 μm, ^; 30 μm, ▵; 100 μm, □). Symbols and vertical bars represent means ±s.e.m. ** P < 0.01 compared with corresponding control response obtained before hexamethonium treatment. Significance of differences was determined at 10 Hz transmural electrical stimulation or with 200 mm acetylcholine.