Figure 1. Effects of different exogenous Ca²⁺ chelators on glucose-induced electrical activity.

Islets were loaded for 1 h at 37 °C in modified Krebs buffer with 100 μmol l⁻¹ of the different exogenous chelators in AM form. The records show representative examples of the effects of 11.1 mmol l⁻¹ glucose on intracellularly recorded membrane potential of a pancreatic β-cell in an intact islet perifused with Krebs buffer. A, unloaded control islet. B, 100 μmol l⁻¹ EGTA-loaded islet. C, 100 μmol l⁻¹ BAPTA-loaded islet. Results are representative of 4 out of 4 cells.