Figure 4. Time-dependent changes in membrane capacitance with low [Ca²⁺]_i.

A, representative time-dependent changes in C_m in control (bottom trace) and in a CST-treated cell. Both cells were dialysed with a pipette-filling solution containing 5 mm EGTA with no added Ca²⁺. Values adjacent to traces indicate resting capacitance. B, mean changes in membrane capacitance (%C_m) relative to resting C_m with low [Ca²⁺]_i determined every 100 s after the start of cytosol dialysis. *Significant differences between the control (•) and CST-treated cells (○, Student's t test, P < 0.01). Differences between control cells and those treated with denatured CST (▾) were found not to be significantly different. Numbers adjacent to points indicate numbers of cells tested.