Table 1. Subthreshold electrophysiological properties of layer 5 pyramidal neurons.
All cells | Regular firing | Burst firing | Weak burst firing | Strong burst firing | |
---|---|---|---|---|---|
Number of cells | 61 | 26 (43 %) | 35 (57 %) | 9 (14 %) | 26 (43 %) |
Membrane potential (mV) | −63.4 ± 0.4 | −63.2 ± 0.6 | −63.5 ± 0.52 | −65.2 ± 1.1 | −62.9 ± 0.5 |
−63 | −63 | −64 | −66 | −63 | |
Minimum 3rd quadrant | 21.1 ± 1.2 | 24.4 ± 2.1 | 18.5 ± 1.3* | 24.6 ± 3.2 | 16.3 ± 0.9†‡ |
peak slope resistance (MΩ) | 17.6 | 22.2 | 16.6 | 24.1 | 15.8 |
Maximum 3rd quadrant | 28.2 ± 1.7 | 34.6 ± 3.1 | 23.2 ± 1.5* | 29.8 ± 2.45 | 21.0 ± 1.6 ‡ |
peak slope resistance (MΩ) | 25.5 | 31.1 | 20.6 | 30.0 | 18.8 |
Minimum 3rd quadrant steady-state slope | 17.0 ± 1.1 | 19.7 ± 1.8 | 15.0 ± 1.2 | 20.8 ± 3.6 | 12.8 ± 0.8†‡ |
resistance (MΩ) | 15.3 | 18.3 | 3.9 | 19.3 | 12.6 |
Maximum 3rd quadrant steady-state slope | 21.2 ± 1.4 | 26.1 ± 2.6 | 17.5 ± 1.2* | 22.82 ± 2.0 | 15.8 ± 1.3‡ |
resistance (MΩ) | 18.98 | 24.5 | 16.1 | 22.4 | 13.6 |
Minimum 1st quadrant | 46.2 ± 4.4 | 61.1 ± 9.2 | 36.3 ± 3.1* | 49.7 ± 5.2 | 31.3 ± 3.3†‡ |
peak slope resistance (MΩ) | 38.9 | 54.0 | 31.8 | 47.1 | 27.6 |
1st quadrant steady-state | 32.2 ± 2.4 | 41.2 ± 3.9 | 26.4 ± 2.5* | 38.1 ± 4.1 | 22.1 ± 2.6†‡ |
slope resistance (MΩ) | 28.58 | 39.8 | 22.5 | 37.3 | 17.9 |
Subthreshold transient | 4.3 ± 0.2 | 3.6 ± 0.3 | 4.75 ± 0.3 | 2.9 ± 0.3 | 5.3 ± 0.3†‡ |
depolarising potential (mV) | 4.3 | 3.3 | 4.8 | 2.7 | 5.5 |
Numerical values are given as means ±s.e.m. (top line) and median (lower line).
Significant difference between burst and regular firing cells (ANOVA).
Significant difference between weak burst and strong burst firing cells (ANOVA).
Significant difference between regular and strong burst firing cells (ANOVA).