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. 1999 Dec 1;521(Pt 2):327–336. doi: 10.1111/j.1469-7793.1999.00327.x

Figure 7. GABA-induced single channel current can be blocked by picrotoxin.

Figure 7

Application of 20 μm GABA to an outside-out patch excised from an oocyte expressing ρ1 GABA receptors induced an inward current, which was blocked when perfusion was briefly switched to GABA (20 μm) plus picrotoxin (100 μm). The holding potential was -200 mV with a [Cl−]i of 20 mm. Note that although the current returns to baseline during the picrotoxin application, some brief channel openings were evident. After removal of the antagonist, the GABA-induced current recovered.