Table 1. Effects of 50 mm ion replacement on reversal potentials and relative permeabilities.
| Reversal potential(mV) | Relative permeability | n | |
|---|---|---|---|
| SCN− | −65.49 ± 1.92 | 11.53 ± 0.89 | 12 |
| I− | −50.51 ± 1.35 | 5.81 ± 0.37 | 21 |
| NO3− | −47.63 ± 0.23 | 4.74 ± 0.37 | 3 |
| Br− | −32.47 ± 1.07 | 2.31 ± 0.13 | 11 |
| Cl− | −20.63 ± 0.40 | 1 | 35 |
| For− | −14.90 ± 0.67 | 0.58 ± 0.04 | 13 |
| HCO3− | −8.99 ± 0.55 | 0.27 ± 0.03 | 14 |
| Ac− | −6.33 ± 1.00 | 0.15 ± 0.04 | 15 |
| Prop− | −5.76 ± 0.75 | 0.12 ± 0.03 | 16 |
| Ise− | −5.18 ± 0.75 | 0.08 ± 0.03 | 5 |
| F− | −4.74 ± 0.66 | 0.06 ± 0.03 | 5 |
| PO4− | −4.26 ± 0.98 | 0.06 ± 0.04 | 15 |
Reversal potentials and relative permeabilities of p1 receptors expressed in oocytes were determined in various ionic conditions. The reversal potentials of GABA-induced currents were measured in solutions with 50 mm (approximately 50%) of the sodium chloride replaced by the sodium salt of the indicated anion. Relative permeabilities were calculated using a rearrangement of the GHK equation as described in the text. Values are means ± s.e.m.; n is the number of cells tested.