Table 2.
Mean rapidly adapting receptor activity (RAR activity; action potentials min−1), mean left atrial pressure (MLAP), mean arterial blood pressure (MABP), heart rate (HR) and peak intratracheal pressure (PITP) during graded increase in left atrial pressure (LAP) when rapidly adapting receptors were investigated before and after an infusion of hypertonic albumin
| Initial control | LAP +5 mmHg | LAP +10 mmHg | Final control | |
|---|---|---|---|---|
| Before hypertonic albumin infusion | ||||
| RAR activity | 20.9 ± 9.5 | 18.8 ± 11.3 | 27.0 ± 11.2 | 17.2 ± 9.8 |
| MLAP (mmHg) | 5.9 ± 1.5 | 10.8 ± 1.4 | 16.3 ± 1.4 | 5.8 ± 1.3 |
| MABP (mmHg) | 72.8 ± 6.1 | 60.4 ± 5.3 | 53.4 ± 5.2† | 64.1 ± 3.4 |
| HR (beats min−1) | 180.4 ± 13.9 | 182.2 ± 8.9 | 175.0 ± 5.1 | 164.0 ± 7.0 |
| PITP (mmHg) | 4.8 ± 0.5 | 5.2 ± 0.6 | 5.8 ± 0.6 | 5.2 ± 0.5 |
| After hypertonic albumin infusion | ||||
| RAR activity‡ | 9.4 ± 3.2 | 30.6 ± 14.6 | 48.9 ± 10.1 | 18.4 ± 7.3 |
| MLAP (mmHg) | 7.3 ± 2.0 | 11.8 ± 2.1 | 16.8 ± 1.8 | 4.6 ± 0.6 |
| MABP (mmHg) | 79.4 ± 4.1 | 65.0 ± 5.0 | 63.2 ± 5.3† | 72.2 ± 4.1 |
| HR (beats min−1) | 153.0 ± 11.1 | 155.4 ± 9.8 | 151.0 ± 12.5 | 154.8 ± 8.1 |
| PITP (mmHg) | 4.5 ± 0.3 | 4.7 ± 0.3 | 5.2 ± 0.3 | 5.0 ± 0.5 |
†
Significantly lower than initial control period (P < 0.05, t test).
‡
Significant change in activity when LAP is increased (P < 0.01, ANOVA and Dunnett's post hoc test).