Table 4.
Total water content and the extravascular water content in the major airways, lungs and the left ventricular muscle, expressed as a percentage of the wet weight
| Upper and Mid-trachea | Lower trachea, carina, bronchi | Right lung (middle and lower lobes) | Left ventricle | |
|---|---|---|---|---|
| Age-matched control rabbits | ||||
| Baseline | 59.4 ± 1.4 | 56.6 ± 1.0 | 80.0 ± 0.6 | 80.0 ± 0.6 |
| n= 5 | (56.1 ± 1.3) | (52.1 ± 1.2) | (75.1 ± 0.9) | (77.5 ± 0.2) |
| LAP +10 mmHg | 59.1 ± 1.0 | 62.5 ± 1.3‡ | 81.3 ± 0.3 | 77.5 ± 0.3 |
| n= 5 | (55.0 ± 1.3) | (57.8 ± 1.7)† | (76.2 ± 0.9) | (76.1 ± 0.3)¶ |
| Rabbits with mitral regurgitation | ||||
| Baseline | 62.4 ± 0.7 | 61.1 ± 1.5† | 80.2 ± 0.2 | 77.6 ± 1.3 |
| n= 7 | (58.4 ± 0.9) | (58.3 ± 1.5)‡ | (74.6 ± 0.4) | (76.7 ± 1.4) |
| LAP +10 mmHg | 63.8 ± 1.5 | 61.0 ± 2.1 | 80.1 ± 1.1 | 78.8 ± 0.4 |
| n= 5 | (59.8 ± 1.5) | (56.9 ± 1.9) | (74.1 ± 1.0) | (77.2 ± 0.6) |
| LAP +25 mmHg | 60.7 ± 1.3 | 65.7 ± 1.1 ‖ | 85.0 ± 1.1§ | 75.8 ± 1.7 |
| n= 5 | (57.3 ± 1.7) | (62.4 ± 1.1)§ | (77.9 ± 1.1)§ | (74.5 ± 1.6) |
Values for the extravascular water content are given in parentheses. LAP, left atrial pressure.
Significantly higher than the corresponding value in age-matched control rabbits at baseline conditions (P < 0.05, t test).
Significantly higher than the corresponding value in age-matched control rabbits at baseline conditions (P < 0.01, t test).
Significantly higher than the corresponding value in rabbits with mitral regurgitation at baseline conditions and at LAP +10 mmHg (P < 0.05, t test).
Significantly higher than the corresponding value in rabbits with mitral regurgitation at baseline conditions (P < 0.05, t test).
Significantly lower than the corresponding value in agematched control rabbits at baseline conditions (P < 0.05, t test).