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. Author manuscript; available in PMC: 2009 Feb 15.
Published in final edited form as: Dev Biol. 2007 Nov 4;314(2):406–417. doi: 10.1016/j.ydbio.2007.10.038

Figure 7.

Figure 7

Loss of pdx1 in the β cell lineage results in increased proliferation of glucagon+ cells and decreased proliferation of insulin+ cells. Co-labelling of e17.5 and e18.5 pancreatic sections for either glucagon (green, A–C) or insulin (green, D–F) and phospho-histone H3 (red, A–F) reveals that in pdx1ΔE2β animals, the fraction of proliferating α cells is increased at e17.5 (compare arrowheads in A with B,C), while the proportion of insulin-expressing β cells actively proliferating is dramatically decreased at e18.5 (compare arrowheads in D with E,F). No difference was observed at e14.5 (not shown).