Figure 4. Comparison of the effects of flufenamic acid (FFA) and niflumic acid (NFA) on I_c and MG channels.

A and B, dose-inhibition curves for the block of I_c by FFA and NFA measured in Ca²⁺-free Ringer solution. Data points show percentage inhibition. The continuous lines are best fits to the data. C, comparison of the maximal MG channel currents (I_max) in response to pressure pulses in cell-attached membrane patches with standard pipette solution (100 mm KCl, 5 mm Hepes-KOH) with and without 100 μM FFA. D, single MG channel I–V relations measured in standard pipette solution with and without 200 μM FFA or 200 μM NFA present.