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. 2000 Mar 1;523(Pt 2):377–389. doi: 10.1111/j.1469-7793.2000.t01-2-00377.x

Figure 3. Carbachol (CCh) strongly depresses the amplitude of basal If in EDS cardiomyocytes.

Figure 3

A, CCh depressed basal If in a representative EDS cardiomyocyte. The effect was completely reversed upon washout (left panel). This is also seen in the time course of this experiment (right panel), the numbers indicate the traces displayed in A (the instantaneous current in presence of CCh was taken as reference for the estimation of the If amplitude). The effect of CCh on If in EDS cells (n= 5) is summarized in the histogram. *Statistically significantly different to control at the P < 0.05 level (paired t test). B, in LDS cardiomyocytes CCh did not depress basal If. (Voltage protocol identical to Fig. 2). 1, control; 2, CCh (1 μM).