Table 1.
Parameters of the dose-response relationships fitted to the mean inhibitory responses of MVN cells to muscimol and baclofen, in each of the experimental conditions
| Muscimol | Baclofen | |||||
|---|---|---|---|---|---|---|
| Max inhibition (%) | EC50 (μm) | Slope | Max inhibition (%) | EC50 (μm) | Slope | |
| Normal MVN (controls) | ||||||
| Rostral cells | 107.9 ± 1.1 | 8.95 ± 0.21 | 1.14 ± 0.02 | 114.7 ± 2.3 | 5.02 ± 0.32 | 0.79 ± 0.02 |
| Caudal cells | 132.5 ± 14.6 | 13.0 ± 3.42 | 0.94 ± 0.09 | 103.4 ± 5.3 | 2.92 ± 0.45 | 0.86 ± 0.09 |
| Ipsi-lesional MVN | ||||||
| Rostral cells | 123.4 ± 7.7 | 45.3 ± 9.5* | 0.78 ± 0.06* | 114.2 ± 7.1 | 20.2 ± 2.2* | 0.59 ± 0.02* |
| Caudal cells | 105.3 ± 10.2 | 10.5 ± 3.45 | 0.79 ± 0.12 | 97.3 ± 12.6 | 3.85 ± 1.89 | 0.69 ± 0.2 |
| Contra-lesional MVN | ||||||
| Rostral cells | 112.9 ± 14.8 | 8.07 ± 2.9 | 0.93 ± 0.14 | 94.5 ± 4.6* | 2.18 ± 0.33* | 1.02 ± 0.12 |
| Caudal cells | 101.4 ± 7.5 | 2.5 ± 0.51* | 1.34 ± 0.29* | 95.1 ± 1.5 | 1.54 ± 0.08* | 0.92 ± 0.04 |
*
Significant difference in parameter after labyrinthectomy compared to control (P < 0.05).