Figure 11. Na⁺ currents through R487V mutant Kv1.5 channels.

A, whole-cell current recordings from Kv1.5-R487V channels in 130 mM ${\text{N }}_{\text{i}}^{+}$/5 mM ${\text{N }}_{\text{o}}^{+}$. The depolarizing pulse was from -80 mV holding potential to +60 mV for 400 ms at 0.05 Hz. B, envelope of tails experiment conducted in symmetrical 135 mM Na⁺. Normalized current data during depolarizations from -80 mV to +60 mV for pulse durations of 50 ms, 350 ms and 14 s (data from a different cell). C, expanded scaled tail current recordings from experiment shown in B.