Table 1. Serotonergic agonist and antagonist effects on inferior olivary neurones.
| Agonist/antagonist | Membrane potential (mV) | Oscillation amplitude (mV) | Oscillation frequency (Hz) | Peak slope of rebound (mV ms−1) | Pre-rectification input resistance (MΩ) | Steady-state input resistance (MΩ) | |
|---|---|---|---|---|---|---|---|
| 5-HT (50 μm) | Pre | −60·4 ± 0·6 | Annihilated | Annihilated | 3·0 ± 0·2 | 56·0 ± 4·0 | 44·0 ± 3·5 |
| Post | −51·0 ± 0·6* | oscillations | oscillations | 0·6 ± 0·2*† | 64·5 ± 5·8† | 49·1 ± 3·5† | |
| (48) | (16/16) | (16/16) | (10) | (20) | (16) | ||
| 5-HT (5 μm) | Pre | −59·0 ± 1·1 | Annihilated | Annihilated | 3·0 ± 0·2 | 56·0 ± 4·0 | 44·0 ± 3·5 |
| Post | −51·3 ± 1·4* | oscillations | oscillations | 0·6 ± 0·2*† | 64·5 ± 5·8† | 49·1 ± 3·5† | |
| (20) | (12/14) | (12/14) | (10) | (20) | (16) | ||
| 5-HT (1 μm) | Pre | −58·3 ± 1·8 | 11·5 ± 4·3 | 6·9 ± 0·3 | n. d. | n. d. | n. d. |
| Post | −58·0 ± 1·8 | 11·6 ± 4·3 | 6·8 ± 0·4 | n. d. | n. d. | n. d. | |
| (4) | (4) | (4) | |||||
| 5-HT + methysergide (5 μm)† | Pre | −60·4 ± 1·3 | 16·5 ± 3·5 | 6·4 ± 0·7 | 2·9 ± 0·2 | 45·6 ± 16·4 | n. d. |
| Post | −59·9 ± 1·3 | 16·4 ± 3·8 | 6·7 ± 0·4 | 2·8 ± 0·1 | 47·1 ± 17·6 | n. d. | |
| (11) | (4) | (4) | (3) | (3) | |||
| 5-HT (5 μm) + ketanserin (1 μm) | Pre | −59·0 ± 1·8 | 10·1 ± 1·8 | 5·4 ± 1·8 | 3·6 ± 0·4 | 48·7 ± 9·8 | 36·9 ± 5·9 |
| Post | −59·3 ± 2·0 | 9·5 ± 1·3 | 5·3 ± 1·8 | 3·6 ± 0·5 | 46·7 ± 7·8 | 31·4 ± 4·9 | |
| (9) | (6) | (6) | (3) | (4) | (4) | ||
| DOI (10—20 μm) | Pre | −60·7 ± 0·6 | Annihilated | Annihilated | 3·1 ± 0·4 | 40·9 ± 17·8 | 32·8 ± 17·4 |
| Post | −51·0 ± 1·6* | oscillations | oscillations | 0·5 ± 0·2* | 69·9 ± 34·2 | 64·6 ± 34·2 | |
| (8) | (3/3) | (3/3) | (3/5) | (4) | (4) | ||
| 8-OH-DPAT (10 μm) | Pre | −58·5 ± 1·7 | 8·3 ± 2·8 | 6·2 ± 0·4 | 2·6 ± 0·3 | 57·9 ± 10·8 | 49·9 ± 7·9 |
| Post | −59·3 ± 1·9 | 8·9 ± 3·5 | 6·1 ± 0·5 | 2·4 ± 0·2 | 56·6 ± 11·4 | 50·6 ± 9·5 | |
| (13) | (4) | (4) | (3) | (8) | (8) |
*
P < 0.05, as compared to Pre.
†
Data pooled for 50 and 5 μm 5HT. Numbers in parentheses are the number of neurones studied. n. d., not determined.