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. 2000 May 15;525(Pt 1):1–9. doi: 10.1111/j.1469-7793.2000.t01-4-00001.x

Figure 2. GABAARs require gephyrin for synaptic cluster formation.

Figure 2

Immunochemistry of cultured hippocampal neurons from wildtype +/+ (A) and geph -/- (gephyrin-deficient) mice (B). After 21 days in vitro, the cultures were stained with antibodies specific for the GABAAR subunit α2. Note the loss of GABAA receptor clusters in neurons from geph -/- mice. These mutant neurons consistently show a significant increase in intracellular GABAA receptor subunit immunoreactivity. Scale bar, 20 μm; applies to both A and B. (Modified from Kneussel et al. 1999a.)